ALPHA BIOTECH : The program to successfully scale your industrial biotech innovation

Are you developing an innovative solution in industrial biotechnology?
ALPHA Biotech helps you de-risk your scale-up and accelerate your path to market.

Alpha Biotech

The Grand Est Region is one of Europe’s leading bioeconomy hubs, officially recognized as a “Regional Innovation Valley.”
It brings together a world-class academic, scientific, and industrial ecosystem and hosts more than 150 bioeconomy startups, 40% of which originate from outside the region — a strong indicator of its international attractiveness.

Industrial biotech startups face major challenges:

  • Access to pilot and demonstration facilities
  • Scaling from lab to industrial level
  • Regulatory constraints
  • Securing growth capital

To help startups overcome these barriers, the Grand Est Region has structured ALPHA Biotech, a dedicated scale-up support program built on:

  • The industrial platforms of CEBB and ARD (TRL 3 to 9) The unique industrial site of the Bazancourt-Pomacle biorefinery
  • A consortium combining scientific, industrial and financial expertise

ALPHA Biotech offers a structured support program built around three complementary pillars to help startups at TRL 4–8 successfully reach industrial deployment.

The program has already demonstrated impact through a 2025 pilot phase.

Verbatim « Having all these stakeholders regularly mobilized around our project saved us a significant amount of time and clearly contributed to our decision to establish operations in the Grand Est. »

Céline Domerc, Co-Founder, AgriLab Leverage

By joining ALPHA Biotech, you can:

Reduce technological and industrial risks

Access real industrial-scale infrastructure

Build a credible financing roadmap

Secure market opportunities and industrial off-take

Strengthen your positioning with investors

Integrate into a structured and active industrial ecosystem

Selected startups benefit from tailored support designed to secure their industrial scale-up.

1. De-risk your technology & industrial scale-Up

Master your transition to industrial scale with coordinated scientific and industrial support:

  • Access regional labs, pilot units and demonstration facilities
  • Optimize bioprocesses and prepare for industrial scaling
  • Leverage CEBB (TRL 2–5) and ARD (TRL 6–9) expertise
  • Benefit from regulatory guidance and connect with regional industrial partners

Objective: secure your technology and ensure industrial robustness.

2. Structure & finance your industrial growth

Strengthen your business and financial trajectory:

  • Refine your business model and development strategy
  • Build a solid financial engineering roadmap
  • Identify and combine relevant public and private funding
  • Receive support for fundraising
  • Connect with specialized biotech investors
  • Access monitoring of national and European funding calls

Objective: secure financing for key development milestones.

3. Accelerate Market Deployment & Territorial Anchoring

Grow your company within a leading industrial bioeconomy cluster:

  • Structure your market access and commercial strategy
  • Connect with industrial partners and value chains
  • Receive support for site selection and regional establishment
  • Access regional investment and innovation schemes
  • Benefit from local biomass availability and strategic resources

Objective: anchor your project in a structured industrial environment that supports long-term growth.

Please note: ALPHA Biotech does not provide direct financial grants.
However, it facilitates access to and optimization of public and private funding instruments.

ALPHA Biotech targets startups and innovative young companies in industrial biotechnology aiming to industrialize and develop operations in the Grand Est Region.

Eligible companies :

  • Incorporated startups
  • Based in France or internationally

Technology scope

  • Bioprocesses and industrial fermentation
  • Bio-based chemistry and enzymes
  • Biomass valorization and co-products
  • Applications in agri-food, energy, materials, chemicals, cosmetics or health (excluding regulated medical biotechnologies)

*non-exhaustive list

Expected maturity level

  • TRL 4 to 8
  • Validated proof of concept
  • Identified need for industrial scale-up or pre-industrial demonstration

Projects will be evaluated based on:

  • Technological innovation and differentiation
  • Technical maturity and scalability potential
  • Market potential and techno-economic viability
  • Economic and environmental impact
  • Credibility of the regional implementation strategy

Application deadline: May 31, 2026. Submit a pitch deck including:

  • Un plan d’affaires
  • R&D roadmap
  • Strategy for establishment or expansion in the Grand Est Region

Applications via: airtable.com

Full confidentiality guaranteed throughout the program and for three years after its completion.

  • May 31, 2026 : Application deadline
  • Early June : Application review
  • Mid-June : Project hearings
  • June 17–20 : Official announcement of selected startups at VivaTech
  • September 2026 : Program start
Grand Est Region
supports the Alpha Biotech program, acting both as a potential funder and as a facilitator to help access the wider ecosystem.
Grand Reims Metropolitan Authority
A local authority strongly committed to the bioeconomy, supporting industrial deployment through site development and access to industrial land.
CEBBEuropean Center for Biotechnology and Bioeconomy
A recognized research and technology institute specializing in technology validation and early-stage scale-up (TRL 2–5).
ARDAgro-Industrie Recherches et Développements
An industrial biotechnology leader since 1989, specialized in industrial bioprocesses, biomass fractionation and bio-based chemistry. ARD supports startups in achieving industrial-scale deployment (TRL 6–9).
InnoRem – University Innovation Hub (URCA)
The innovation arm of the University of Reims Champagne-Ardenne, with bioeconomy positioned at the core of its strategic roadmap.
Bpifrance – French Public Investment Bank
A key partner in supporting and financing high-growth companies, providing tailored funding solutions and strategic advisory services.
B4CBioeconomy For Change (B4C)
One of Europe’s leading bioeconomy clusters, supporting companies through technical expertise and a network of over 500 industrial and innovation partners.compétences techniques qu’il possède en interne mais aussi grâce son large réseau (+500 membres).
Quest for bioeconomyQuest for bioeconomy
A sector-focused incubator dedicated to the bioeconomy, part of the Quest for Change network. It supports more than 200 startups in business structuring, financial engineering and market development.

Contact us

By e-mail : bioeconomie@grandest.fr

Online : https://www.bioeconomie-grandest.fr/contact